Optical Design for Biomedical Imaging (SPIE Press Monograph by Rongguang Liang

By Rongguang Liang

Designing an effective imaging procedure for biomedical optics calls for a great figuring out of the designated requisites of the optical platforms for biomedical imaging and the optical elements utilized in the platforms. although, an absence of reference books on optical layout (imaging and illumination) for biomedical imaging has resulted in a few inefficient platforms. This booklet fills the space among biomedical optics and optical layout via addressing the basics of biomedical optics and optical engineering, and biomedical imaging platforms. the 1st part presents a quick creation to biomedical optics after which covers the basics of optics, optical elements, gentle assets, detectors, optical imaging method layout, and illumination process layout. This additionally comprises very important matters relating to biomedical imaging, corresponding to autofluorescence from optical fabrics. the second one half the textual content covers numerous biomedical imaging suggestions and their optical platforms, in addition to layout examples.

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An aperture stop is the aperture of one component in the optical system that limits the bundle of light from an on-axis object point that can propagate through the system. An aperture stop can be a lens aperture or a separate physical aperture in the optical path. The image of the aperture stop in the object space is called the entrance pupil, which limits the cones of light entering the system. The image of the aperture stop in the image space is the exit pupil, which defines the cone of the light exiting the system.

Similarly, the object and image distance (l and l ′) are the distances from the object and image planes to their respective principal planes. The back focal length (BFL) is the distance from the last surface of the system to the back focal point F , and the front focal length (FFL) is the distance from the first surface to the front focal point F. The working distance is defined as the distance from the first lens surface to the object, which is (FFL + z) in the figure. The field of view (FOV) of an optical system is the diameter of the object or the maximum angular size of the object.

It is dependent on aperture and does not have through-focus symmetry . Doubling the aperture results in 16 times the wavefront aberration. 2 Coma W131 H3 cos  Coma is an off-axis aberration due to the variation of image location and size with the zonal radius in the pupil for an off-axis object point. It can also be regarded as the variation of magnification with pupil position since the size of the ring increases as the radial zone moves out to the edge of the pupil. 13 Plots of transverse ray and wavefront aberrations in the presence of spherical aberration (a) without and (b) with compensating defocus.

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