Molecular Nutrition and Genomics: Nutrition and the Ascent by Mark Lucock

By Mark Lucock

This interesting booklet attracts it material from quite a number suitable disciplines that stretch from molecular nutrients, dietary sciences, and nutrients dietetics via to genetics, genomics, and anthropology. It provides an essential portrait of the completely basic position that meals has performed and keeps to play in shaping who and what humans are, in addition to the place they advanced from, and the place they are heading as a species.

Molecular foodstuff: nutrients and the Evolution of Humankind:

  • Blends insurance of the molecular mechanisms that underpin nutrient-gene interactions with evolutionary theory
  • Takes a molecular organic method of challenge fixing, and strikes foodstuff clear of its dietetic and anthropological origins to front traces of genomic research
  • Covers key recommendations in molecular biology; the –omics revolution and bioinformatics; fresh human evolution; molecular mechanisms of gene-nutrient interactions; the significance of food and genomics in affliction; the evolution of micronutrient metabolism, protein constitution, and human illness; foodstuff and the human lifecycle; modern nutritional styles; modern laboratory instruments in nutrigenomics and human evolutionary studies

Written through an the world over acknowledged professional within the box, Molecular foodstuff: nutrients and the Evolution of Humankind is a useful textual content and reference ebook for a variety of lecturers, scholars, and researchers.

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Extra resources for Molecular Nutrition and Genomics: Nutrition and the Ascent of Humankind

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53) recently showed that the frequency of Pro11Leu allelic frequency varied widely among 11 extant human populations with differing ancestral diets. 3% in Chinese who have a more mixed ancestral diet. Using the genetic distance measure FST , these authors conclude that the frequency of this allele has been shaped by dietary selection pressure. 8 for explanation and further reference). It is recognized that in the presence of a low folate status, this mutant allele is associated with elevated homocysteine, and aberrant epigenetic processes, both of which are thought to be key factors in vascular disease and cancer (20,25).

Important micronutrient–gene interactions, with particular reference to the effect of certain vitamins and minerals on the genomic machinery and/or gene product. Some Important Micronutrient–Gene Interactions Dietary Component Background Information Retinoic acid (vitamin A) RXR forms homodimers and heterodimers with vitamin D, PPAR, thyroid hormone, and COUP receptors Ascorbic acid (vitamin C) Oxidative DNA damage in vitamin C depletion (formation of 8hydroxyguanine) Modulates responsiveness of steroid hormone receptor Pyridoxal Phosphate (vitamin B6 ) Riboflavin (vitamin B2 ) Flavin cofactor for 5,10MTHFR Folic acid Provides 1-C unit for purine, pyrimidine, and methyl groups Vitamin D Vitamin D receptor forms a heterodimer with RXR Growth arrest specific gene 6 product contains γ -carboxyglutamate residues Antioxidant properties.

By contrast, many northern Europeans, northern Africans, and Arab populations maintain their ability to digest lactose into adulthood, and they have a high digestive capacity. The dominant LAC P gene controls adult lactose digestion: Either one or two alleles confer high digestive capacity. By contrast, homozygosity for the recessive allele LAC R confers low digestive capacity. The genetic distribution of LAC P may stem from the environmental pressures of a nomadic lifestyle in some northern African and Arab populations.

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