Mechanisms of insulin action by Alan R. Saltiel, Jeffrey E. Pessin

By Alan R. Saltiel, Jeffrey E. Pessin

More than 18 million humans within the usa have diabetes mellitus, and approximately ninety% of those have the kind 2 type of the sickness. additionally, among 17 and forty million humans have insulin resistance, impaired glucose tolerance, or the cluster of abnormalities noted variably because the metabolic syndrome, the dysmetabolic syndrome, syndrome X, or the insulin resistance syndrome. In all of those problems, a critical element of the pathophysiology is insulin resistance, i.e., lowered responsiveness to insulin in tissues resembling muscle, fats and liver. Insulin resistance can also be heavily associated with different universal illnesses, together with weight problems, polycystic ovarian disorder, hyperlipidemia, high blood pressure, and atherosclerosis. during this ebook, we are going to try to dissect the complexity of the molecular mechanisms of insulin motion with a different emphasis on these gains of the approach which are topic to alteration in kind 2 diabetes and different insulin resistant states. We discover insulin motion on the most simple degrees, via complicated platforms. The booklet could be attractive to uncomplicated and scientific scientists.

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172. Marino-Buslje C, Martin-Martinez M, Mizuguchi K et al. The insulin receptor: From protein sequence to structure. Biochem Soc Trans 1999; 27:715-726. 173. MoHna L, Marino-Buslje C, Quinn DR et al. Structural domains of the insuUn receptor and IGF receptor required for dimerisation and ligand binding. FEBS Lett 2000; 467:226-230. 174. Brandt J, Andersen AS, Kristensen C. Dimeric fragment of the insulin receptor alpha-subunit binds insulin with full holoreceptor affmity. J Biol Chem 2001; 276:12378-12384.

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Biochem Soc Trans 1999; 27:715-726. 173. MoHna L, Marino-Buslje C, Quinn DR et al. Structural domains of the insuUn receptor and IGF receptor required for dimerisation and ligand binding. FEBS Lett 2000; 467:226-230. 174. Brandt J, Andersen AS, Kristensen C. Dimeric fragment of the insulin receptor alpha-subunit binds insulin with full holoreceptor affmity. J Biol Chem 2001; 276:12378-12384. 175. Surinya KH, Molina L, Soos MA et al. Role of insulin receptor dimerization domains in ligand binding, cooperativity, and modulation by anti-receptor antibodies.

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