By Corinne M. Spickett, Henry Jay Forman
Oxidative amendment of lipids and phospholipids―including radical harm, halogenation, and nitration―result in major alterations to the chemical homes of the molecules, which in flip have an important impression on their biochemical services. Lipid oxidation has lengthy been considered as a deleterious technique answerable for lipid rancidity, lack of functionality, and iteration of poisonous items. notwithstanding in recent times, learn has additionally desirous about the non-detrimental physiological and pathological results of those chemical reactions. Lipid Oxidation in wellbeing and fitness and Disease presents an up to date evaluate of the function of oxidized lipid items in physiological and pathophysiological processes.
Covering the various subject matters that give a contribution to investigate during this vital box, this publication explores:
- The mechanisms of lipid oxidation, either enzymatic and non-enzymatic
- Antioxidant defenses and lipid oxidation
- Lipid oxidation items and cellphone signaling
- The roles of oxidized lipids in particular diseases―including cardiovascular, neurodegenerative, and metabolic problems, in addition to in cancer
- Drug concentrating on and the healing capability of oxidized lipids
Accurate dimension of the formation of lipid oxidation items and research in their organic results and roles in disorder are severe to biomedical technology and new precise therapeutics. Written by means of stated specialists within the box, this e-book presents a huge survey of either validated wisdom and up to date findings at the motion of oxidized lipid items on mobile signaling and gene expression in well-being and ailment.
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Additional resources for Lipid Oxidation in Health and Disease
Lau, H. , Han, K. , Miller, E. , Curtiss, L. , Witztum, J. , and Strauss, B. H. 2004. Percutaneous coronary intervention results in acute increases in oxidized phospholipids and lipoprotein(a): Short-term and long-term immunologic responses to oxidized low-density lipoprotein. Circulation, 109, 3164–70. Turrens, J. F. 2003. Mitochondrial formation of reactive oxygen species. J Physiol, 552, 335–44. , and Aldini, G. 2013. Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): An overview of their mechanisms of formation.
Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in heart failure after myocardial infarction. Free Radic Biol Med, 43, 271–81. , Myher, J. , and Kamido, H. 1996. Isolation and identification of glycated aminophospholipids from red cells and plasma of diabetic blood. FEBS Lett, 381, 77–81. , and Shaikh, N. A. 2000. Glucosylated glycerophosphoethanolamines are the major LDL glycation products and increase LDL susceptibility to oxidation: Evidence of their presence in atherosclerotic lesions.
Olsen, T. , and Ferrington, D. A. 2007. Age-related macular degeneration and retinal protein modification by 4-hydroxy-2-nonenal. Invest Ophthalmol Vis Sci, 48, 3469–79. Ford, D. A. 2010. Lipid oxidation by hypochlorous acid: Chlorinated lipids in atherosclerosis and myocardial ischemia. Clin Lipidol, 5, 835–852. 18 Lipid Oxidation in Health and Disease Forman H. J. and Boveris, A. 1982. Superoxide radical and hydrogen peroxide in mitochondria. In: Pryor WA, editor. Free Radical in Biology, New York: Academic Press; pp.