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Additional info for Hormone Action Part J: Neuroendocrine Peptides
1° As an alternative to the use of chemical oxidizing agents, enzymatic oxidation systems have been widely applied to the radioiodination of peptides, using either the enzyme lactoperoxidase with hydrogen peroxide added as a cofactor, ~ or, in order to avoid adding even small amounts of this oxidizing agent, lactoperoxidase plus a glucose-glucose oxidase system to generate hydrogen peroxide as required, n The Chloramine-T Method Two main variables of this method have been extensively investigated: the concentration of and time of exposure to chloramine-T, and the concentration and nature of the reducing agent used to quench the reaction.
However, in practice, it has been found that active iodine species may be carried forward from the reaction tube and these may subsequently label carrier proteins etc. added to the tracer solution. 9 Such 4 W. M. H u n t e r and F. C. Greenwood, Nature (London) 194, 495 (1962). 5 M. R. R e d s h a w and S. S. L y n c h , J. Endocinol. 60, 527 (1974). 6 W. R. Butt, J. Endocrinol. 55, 453 (1972). 7 p. Reay, Ann. Clin. Biochem. 19, 129 (1982). 8 p. j. Fraker and J. C. Speck, Biochem. Biophys. Res.
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