Greenspan's Basic and Clinical Endocrinology, Ninth Edition by David Gardner, Dolores Shoback

By David Gardner, Dolores Shoback

The popular one-stop advisor to the full box of scientific endocrinology and its medical underpinnings – now in complete color

270+ full-color photos and illustrations!

A Doody's middle name for 2011!

4 superstar DOODY'S REVIEW!
"This is a wonderful assessment of the fundamental body structure and medical elements of endocrinology for trainees. the dimensions of the e-book and the well-written textual content, supported by means of visible aids, make this a handy ebook to learn and strengthen a starting starting place in endocrinology."--Doody's evaluation Service

Greenspan’s easy & scientific Endocrinology, 9e provides a succinct, modern evaluation of the underlying molecular biology of the endocrine method and the most recent views at the analysis and remedy of particular illnesses and issues. that includes an better layout that incorporates 1000s of full-color illustrations and medical photos, Greenspan’s is a real must-have in the course of conventional or built-in classes in endocrinology, endocrinology rotation, or for examination prep in inner medication and endocrinology.

Greenspan’s presents clinically correct insurance of metabolic bone illness, pancreatic hormones and diabetes mellitus, hypoglycemia, weight problems, geriatric endocrinology, and lots of different illnesses and issues. helping this crucial fabric is a convenient appendix of ordinary hormone reference ranges.


  • Concise, balanced insurance of either medical and scientific rules
  • the easiest resource for present recommendations in endocrine pathophysiology to help medical choice making
  • vital new methods to the clinical administration of endocrine problems, together with healing strategies
  • the main functional, present insights into diagnostic checking out
  • More than 270 full-color illustrations and medical photographs

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Additional resources for Greenspan's Basic and Clinical Endocrinology, Ninth Edition

Example text

In addition to their effects on tran­ scription, coactivators have been suggested ro be involved in transcript elongation, RNA splicing, and mRNA transport. Recent studies have shown that a significant portion of ER DNA-binding sires in MCF7 lines (breast cancer cell line) are topographically linked to, or in some cases directly overlap with, rhose for the forkl1ead box transcription factor A 1 (FOX A 1 ) . FOX A1 has been referred to as a pioneer factor rhar aids i n posi­ tioning ER (or AR) at specific sires on DNA.

These cell membrane receptors have a single internal hydrophobic stretch of amino acids, suggesting that they span the membrane but once (see Figure 1-4) . They can be composed of monomers or het­ erodimers of different molecules. Growth Hormone a nd Prolactin Receptors Receptors for GH and prolactin are prototypical cytokine recep­ tors (Figure 1-1 1 ) . Interestingly, altet·native splicing of the GH recepror gene primary transcript results in a foreshortened "recep­ ror" that lacks the membrane anchor and carboxyl terminal domain of the protein.

The PR displays a novel ability to interact with the SH3 domains of the Src family tyrosine kinases, thereby accessing the Ras/Raf/MEK- 1 / ERK signaling pathway (discussed earlier) . Although we still do not completely understand the mechanisms underlying these nongenomic effects, their potential importance in medi­ ating steroid or thyroid hormone action may, in selected instances, approach that of their more conventional genomic coun terparrs. Neurosteroids represent another class of nontraditional hor­ monal agonists with unique biologic activity.

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