Gene-Environment Interactions in Developmental by Kenneth A. Dodge PhD, Michael Rutter MD

By Kenneth A. Dodge PhD, Michael Rutter MD

Bringing jointly optimum specialists, this ebook studies groundbreaking gene–environment learn and explores implications for medical perform, prevention, and public coverage. offered is state of the art paintings at the interaction of genetic components and youth reports within the improvement of psychological problems resembling melancholy, behavior ailment, and schizophrenia. crucial themes comprise what scientists presently learn about "susceptibility genes"; the mechanisms wherein maltreatment and different stressors have interaction with organic susceptibilities throughout improvement; and elements that verify kids extra resilient than others. destiny instructions for personalizing remedy and prevention efforts, hence making them more suitable, are mentioned.

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2008). The case of the missing heritability. Nature, 456, 18–21. , Werker, J. , & Gerken, L. (2002). Infant sensitivity to distributional information can affect phonetic discrimination. Cognition, 82, B101–B111. McGowan, P. , D’Alessio, A. , et al. (2009). Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nature Neuroscience, 12, 342–348. Meaney, M. J. (2010). Epigenetics and the biological definition of gene × environment interactions. Child Development, 81, 41–79.

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Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386–389. , Craig, I. , Milne, B. , et al. (2007). Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism. Proceedings of the National Academy of Sciences of the USA, 107, 18860–18865. Eaves, L. J. (2006). Genotype × environment interaction in psychopathology: Fact or artefact? Twin Research in Human Genetics, 9, 1–8. Gottesman, I. , & Gould, T. D. (2003). The endophenotype concept in psychiatry: Etymology and strategic intentions.

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