Focus on Homocysteine and the Vitamins: Involved in its by Christina Bolander-Gouaille

By Christina Bolander-Gouaille

During the final 10-12 years, the learn on homocysteine has turn into very lively. approximately 1500 of articles are actually released every year on homocysteine and the supplementations concerned with its metabolism. A disturbed homocysteine metabolism might be an underlying issue for being pregnant problems and fetal malformations, heart problems, dementia, psychiatric and neurologic problems and doubtless carcinogenesis. A disturbed homocysteine metabolism can normally be normalised by means of therapy with folate and/or vitamines B12 and B6. a lot of those findings for this reason at once situation such a lot practitioners. besides the fact that, if there are reliable reports overlaying unmarried features of this learn, those are released in specialized journals. the writer has realised the problems for the practitioner in preserving up to date. This moment variation has been completely up to date and likewise bargains extra info at the supplementations. Over 1600 references are made available.

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2000 ). This suggests that some of the adverse effects of homocysteine, which are related to arachidonic acid metabolism, may depend on the formation of thromboxane A2 , a potent vasoconstrictor and inducer of platelet aggregation. Total Hcy was also related to neopterin (a monocyte-derived inflammatory mediator) and endothelin-1, bothin patients with disturbed glucose metabolism and in controls, which again suggests an influence of Hcy on vascular function through interference with endothelial and leucocyte function {Gottsaker et al.

05 .. 01 n=17 Fig 4. Plasma homocysteine concentrations and flow-mediated dilatation (mean +I- SEM, n=17) 4 hours after fruit juice alone (vehicle) and after methionine 10, 25, 100 mg/kg. 01 compared with responses after fruit juice alone. Chambers J et a/. Physio/ogica/ increments in p/asma homocysteine induce vascular endothelial dysfunction in normal human subjects. Arteriosclerosis and Thrombosis. 1999;19:2922-27. ©1999 Am Heart Association lnc. Reprinted with permission. The finding in several placebo-controlled studies that Hcy-lowering vitamin treatment significantly improves flow-mediated endothelial response, page 135, considerably strengthens the association between tHcy and EDD.

1999) • Promotion of smooth muscle cell proliferation (Tsai JC et al. 1994, Carmody et al. 1999, Chen CY et al. 2ooo, Woo DK et al. 2000), an effect counteracted by folic acid (Carmody et al. 1999) • CoUagen accumulation (Majors et al. 1997, Tygai et al. 1998a,b) possibly caused by the induction of metalloproteinases-1 (Rodriguez JA et al. 1999) • Diminished adrenergic vasoconstriction of resistance arteries (Cipolla et al. 2000) Enhancement of lipoprotein(a)-fibrin binding (Harpel et al. 1992) On coagulation: • Enhanced low density lipoprotein oxidation (Heinecke et al.

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