By Victor M. Montori
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Additional info for Evidence-Based Endocrinology (Contemporary Endocrinology)
They surveyed 42,000 obstetricians and pediatricians in 18 countries, obtaining data on 395 unpublished trials. To deal with the problem of publication bias they set up registers for published, unpublished trials and planned trials. They collected overviews or meta-analyses, conducted according to explicit procedures and regularly updated. They published their work in an edited collection, Effective Care in Pregnancy and Childbirth (41) with the database itself published as the Oxford Database of Perinatal Trials (42).
Writing Group for the Women’s Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA 2002;288: 321–333. 24. Moseley JB, OMalley K, Petersen NJ, et al. A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med 2002;347:81–88. 25. Deyo RA, Psaty BM, Simon G, Wagner EH, Omenn GS. The messenger under attack—intimidation of researchers by special-interest groups.
He had to be trained in epidemiology and biostatistics in order to conduct surveys of disease outbreaks and found the work soul-destroying. Then, in 1963, he read Feinsteins’s paper Boolean Algebra and Clinical Taxonomy (31) and was converted to try to work at the interface between clinical medicine and epidemiology and biostatistics. In 1967 Sackett was at the State University of New York, Buffalo, establishing himself in the Department of Medicine, when he was invited to come for an interview to McMaster University.