Drug Therapy for Type 2 Diabetes by Andrew Krentz

By Andrew Krentz

This Adis Pocket Reference offers an updated, succinct, and functional method of drug remedy for variety 2 diabetes.

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2009;360:129-39. Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet. 2005;365:1415-28. European Diabetes Working Party for Older People 2001-2004. Clinical guidelines for type 2 diabetes mellitus (older people). pid=30. Accessed 2011 June 9 Gregg EW, Cheng YJ, Saydah S, et al. S. adults with and without diabetes between 1997 and 2006. Diabetes Care 2012;35:1252-57. Holman RR, Paul SK, Bethel MA, et al. 10-Year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med. 2008;359:1577-89.

G. during myocardial ischaemia. However, there is no clear evidence that therapeutic concentrations of sulphonylureas exert such an effect. This controversy continues, and has been fuelled by reports from non-randomised studies suggesting that some, generally older, sulphonylureas are associated with a worse prognosis after myocardial infarction. Other data refute this assertion. 4. Meglitinides Meglitinide, the non-sulphonylurea moiety of glibenclamide, which contains the benzamido group, stimulates insulin secretion.

In a second randomisation strategy, patients were assigned to either insulinprovision therapy – an insulin secretagogue or insulin – or rosiglitazone. Survival rates were similar between the groups, and the results have been interpreted as reassuring with respect to the safety of rosiglitazone in highrisk cardiac patients. A recently published observational study using data from UK general practice concluded that pioglitazone was superior to rosiglitazone in mortality outcomes. Methodological limitations demand a cautious interpretation of these data.

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