By Lewis E. Braverman
This largely revised and up-to-date version of a favored and commonly acclaimed paintings offers the most recent clinical and medical advancements in thyroid ailment. New issues contain the medical relevance of the sodium/iodide symporter (NIS), huge assurance of autoimmune thyroid sickness, and extended assurance of thyroid melanoma, together with recombinant human TSH. different chapters talk about thyroid disorder while pregnant and postpartum, thyroid affliction in young children and the aged, and the assessment and administration of nodular goiter. ailments of the Thyroid, 2d version, offers internists and kin physicians, obstetricians and gynecologists, and endocrinologists alike with a hugely readable consultant to thyroid issues and their medical administration.
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Additional info for Diseases of the Thyroid (Contemporary Endocrinology)
Endocrinology 1996;137:4744–4751. 53. Storey NM, O’Bryan JP, Armstrong DL. Rac and Rho mediate opposing hormonal regulation of the ether-ago-go related potassium channel. Curr Biol 2002;12:27–33. 54. Incerpi S, Luly P, deVito P, Farias RN. Short-term effects of thyroid hormones on the Na/H antiport in L-6 myoblasts: high molecular specificity for 3,3′,5-triiodo- L -thyronine. Endocrinology 1999;14: 683–689. 55. Gekle M, Freudinger R, Mildenberger S, Schenk K, Marschitz I, Schramek H. Rapid activation of Na+/H+-exchange in MDCK cells by aldosterone involves MAP-kinases ERK1/2.
Puymirat J, Etongue-Mayer P, Dussault JH. Thyroid hormones stabilize acetylcholinesterase mRNA in neuro-2A cells that overexpress the beta1 thyroid receptor. J Biol Chem 1995;270:30,651–30,656. 91. Theriault A, Ogbonna G, Adeli K. Thyroid hormone modulates apolipoprotein B gene expression in HepG2 cells. Biochem Biophys Res Commun 1992;186:617–623. 92. Freedman RB, Hirst TR, Tuite MF. Protein disulphide isomerase: building bridges in protein folding. TIBS 1994;19:331–336. 93. Yoshida K, Davis PJ, Schoenl M.
The principal cardiovascular actions of TH nonetheless are seen to be genomic in mechanism (29,30). There are several other nonnuclear cellular effects of the hormone whose systemic roles appear to be of interest. Among such effects are the action of 3,3’-diiodothyronine (T2) on cytochrome c oxidase activity in mitochondria (31,32), an effect that may contribute to modulation by TH of cell and organ respiration, and which raises the possibility that deiodination of T3 may result in a biologically important analogue.