By Vivian Fonseca, Merri Pendergrass, Roberta Harrison McDuffie
Diabetes in medical perform is a pragmatic guide at the analysis, therapy and administration of style 2 diabetes. It covers all components of the therapy and administration of sort 2 diabetes, from sufferer schooling on matters akin to fit consuming and workout to the potential scientific remedies and medication to be had. As such, this e-book aids in either without delay treating the disorder and dealing in the direction of the prevention of any pointless problems which may come up out of residing with this condition.
Concise, but thorough, Diabetes in medical perform is a worthy significant other to these relations practitioners and different clinicians who're confronted with this more and more common disease.
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Extra info for Diabetes in Clinical Practice
Like SUs, they stimulate insulin secretion by binding to the SU receptor. They have a more rapid onset and shorter duration of action than the SUs and are designed to target postprandial hyperglycemia. They should be taken just prior to meals. Repaglinide is similarly effective at A1C reduction as metformin and the SUs , while nateglinide is less effective . Compared to SUs, the risk for hypoglycemia is similar with repaglinide but less frequent with nateglinide. Glinides are not commonly used in the USA, most likely because of their higher cost, more frequent dosing, and reduced efficacy (nateglinide) compared to SUs.
Initiate Insulin by Aggressive Titration and Education (INITIATE): a randomized study to compare initiation of insulin combination therapy in type 2 diabetic patients individually and in groups. Diabetes Care 2007; 30:1364–1369. 29 Schwartz S, Sievers R, Strange P, et al; INS-2061 Study Team. Insulin 70/30 mix plus metformin versus triple oral therapy in the treatment of type 2 diabetes after failure of two oral drugs: efficacy, safety, and cost analysis. Diabetes Care 2003; 26:2238–2243. 30 Triplitt C, Glass L, Miyazaki Y, et al.
4 Lowering A1C reduces complications in type 1 and type 2 diabetes DCCT Kumamoto A1C reduction 9% to 7% 9% to 7% 8% to 7% Retinopathy Q 76% 69% 17– 21% Neuropathy Q 50% Significantly improved – – 16% Macrovascular disease Q 41% UKPDS DCCT, Diabetes Control and Complications Trial; UKPDS, UK Prospective Diabetes Study. Data from [5–7]. 5 Risk reduction with treatment of diabetes Microvascular events Macrovascular events Blood pressure treatment 20–40% 20–50% Lipid treatment – 25–55% Glucose treatment 12–35%* 10–20%* *Per 1% A1C reduction.