By Anil Bhansali, Anuradha Aggarwal, Girish Parthan, Yashpal Gogate
This booklet on pediatric endocrinology covers fascinating and but usually demanding situations between pediatric sufferers in a different Question-Answer layout. Simulating the bed-side case discussions throughout the ward rounds, one query logically ends up in one other, thereby producing interest and selling evidence-based medication. Taking the readers throughout the complete spectrum ranging from etiology and pathophysiology to scientific presentation to administration ideas, every one query addresses one key point of the affliction. defined in a very easy and lucid narrative, this publication guarantees sound conceptual figuring out whereas overlaying every one subject comprehensively. This quantity covers vital issues reminiscent of brief stature, pubertal problems, thyroid problems, formative years Cushing syndrome, rickets and osteomalacia, ailment of sexual differentiation and diabetes within the younger. much less universal affliction corresponding to a number of endocrine neoplasia has additionally been included. those situations aren't in simple terms obvious by means of endocrinologists, yet also are controlled through paediatricians, internists, obstetricians and gynaecologists, orthopaedicians and surgeons.
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Extra resources for Clinical Rounds in Endocrinology: Volume II - Pediatric Endocrinology
GH response to provocative stimuli is essentially normal in children with ISS; however, serum IGF1 levels are variable. 14). 30 a 1 Disorders of Growth and Development: Clinical Perspectives b Fig. 14 (a) A 12-year-old girl with familial short stature along with her father (who is also short). (b) X-ray wrist AP view showing bone age of 12 years 42. How to differentiate between familial short stature and constitutional delay in growth and puberty? FSS and CDGP are normal variants of short stature and are associated with a strong family history.
This can be due to either short limb or short trunk. 7). An approach to a short child is depicted in the figure given below (Fig. 8). a b Fig. 7 (a) Siblings with short stature due to mucopolysaccharidosis. (b) Lateral spine radiograph showing reduced vertebral height with anterior beaking of the lower dorsal vertebral bodies in the same patient 1 Disorders of Growth and Development: Clinical Perspectives 17 Short stature Dysmorphic features Present • • • • • • Absent Proportionate short stature Turner’s syndrome Down’s syndrome Noonan’s syndrome Prader-Willi syndrome Russell-Silver syndrome Pseudohypoparathyroidism Overweight for height • GHD • Cushing’s syndrome Disproportionate short stature Short limbs Normal weight for height • CDGP • FSS Underweight for height • Chronic system disease • Malnutrition • • • • Hypothyroidism Rickets Achondroplasia Osteogenesis imperfecta Short trunk • Mucopolysaccharoidosis • Kyphoscoliosis • Spondyloepiphyseal dysplasia Fig.
Disease Turner syndrome Noonan syndrome Down syndrome Prader–Willi syndrome Russell–Silver syndrome Laurence–Moon–Bardet–Biedl syndrome Seckel syndrome GH deficiency due to congenital hypothalamo–pituitary defects Pseudohypoparathyroidism Dysmorphic features Micrognathia, low-set ears, low posterior hairline, short webbed neck, lymphedema, shield chest, cubitus valgus, short fourth and/or fifth metacarpals, cardiac anomalies (left sided), renal anomalies Hypertelorism, down-slanting eyes, short webbed neck, low posterior hairline, right-sided cardiac anomalies, hypertrophic cardiomyopathy, mental retardation, cryptorchidism Mongoloid slant of eyes, developmental delay, umbilical hernia, simian crease, large protruding macroglossia, sandal toe Obesity, hypotonia, hypogonadism, mental retardation Small triangular facies, facial asymmetry, clinodactyly, hemihypertrophy, micrognathia Obesity, polydactyly, hypogonadism, retinitis pigmentosa Microcephaly, beaking of nose, micrognathia, craniosynostosis Cleft lip, cleft palate, single central incisor, bifid uvula, nystagmus, rigid cervical spine (short neck) Albright hereditary osteodystrophy phenotype (round face, short fourth and/or fifth metacarpals, obesity, subcutaneous ossification) 1 Disorders of Growth and Development: Clinical Perspectives Fig.