Carnitine Biosynthesis, Metabolism, and Functions by Rene A. Frenkel

By Rene A. Frenkel

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R. FRENKEL: The only origin so far proven for trimethyllysine in animals is as you indicate. I agree that the circulating concentrations of TML are very low, but in our experiments we have observed more than a trivial uptake by the kidney. D. SACHAN: Do you have carbon balance on the distribution of trimethyllysine or hydroxy trimethyllysine when given "in vivo" and uptake by different organs measured with time? R. FRENKEL: We have not measured the complete transformations in every tissue and our observations have been limited to kidney, liver, heart and skeletal muscle.

35: 1478 (1976). Hülse, J. , Ellis, S. R. and Henderson, L. , J. Biol. Chem. 253:1654-1659 (1978). Kaufman, R. A. and Broquist, H. , J. Biol. Chem. 252: 7437-7439 (1977). , Myllylae, R. and Kivirikko, Κ. , Eur. J. Biochem. 80:341-348 (1977). Schirch, L. , J. Biol. Chem. 243:5651-5655 (1968). , Takio, K. , J. Biol. Chem. 251:236-240 (1976). Greenfield, N. J. , Biochim. Biophys. Acta 483:35-45 (1977). DISCUSSION R. ESTABRQOK: Could you summarize the evidence that your 8 enzyme is really a hydroxylase?

LaRhee Henderson should respond to this LaRHEE HENDERSON: We have not tested whether catalase will prevent the inactivation of trimethyllysine hydroxylase by 2 + F e , but we do know that ascorbate or dithiothreitol will 2 + protect from F e . H. BROQUIST: What is the source of Dr. Schirch's serine transhydroxymethylase? L. HENDERSON: Rabbit liver. H. BROQUIST: Have you ever seen reduction of γ-butyrobe­ taine aldehyde to the equivalent alcohol? L. HENDERSON: No, not to date. We have tried to reduce the aldehyde using NADH or NADPH, but we have found no evidence for reduction of the aldehyde to the alcohol.

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