Calcium in Human Health by Connie M. Weaver, Robert P. Heaney

By Connie M. Weaver, Robert P. Heaney

This finished assessment of the country of our wisdom touching on calcium not just demonstrates its value to human healthiness, but additionally defines its many complicated roles. The authors summarize the newest uncomplicated clinical info at the mobile and metabolic services of calcium, explaining the prime innovations for appropriately measuring its bioavailability, absorption, and kinetics, and displaying that calcium deficiency is an enormous challenge whereas calcium extra an extraordinary one. additionally they study the advanced legislation of calcium absorption, distribution, and excretion, in addition to the a number of interactions of diet/lifestyle, and actual task in calcium homeostasis. Their dialogue of the explicit roles of calcium in a number of medical disorders-osteoporosis, oral well-being, weight problems, reproductive issues, and the metabolic syndrome-provides new insights and increases new questions. The advanced adjustments in calcium and phosphate law that take place in renal illness and the capability position of calcium in high blood pressure and vascular affliction also are addressed.

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Hughes AR, Thastrup O, and Putney JW, Jr. Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool and not an inositol phosphate regulate calcium fluxes at the plasma membrane. J Biol Chem 1989;264:12,266– 12,271. 45. Putney JW, Jr. Capacitative calcium entry revisited. Cell Calcium 1990;11:611–624. 46. Putney JW, Jr, Bird GSJ. The inositol phosphate-calcium signaling system in no-excitable cells. Endocr Rev 1993;14:610–631.

Putney JW Jr. Type 3 inositol 1,4,5-trisphosphate receptor and capacitative calcium entry. Cell Calcium 1997;21:257–261. 13. Fagan KA, Graf RA, Tolman S, Schaack J, Cooper MF. Regulation of a Ca2+-sensitive adenylyl cyclase in an excitable cell. Role of voltage-gated versus capacitative Ca2+ entry. J Biol Chem 2000;275:40,187– 40,194. 14. Herms I, Schneider J, Dewachter I, Caluwaerts N, Kretzshmar H, Van Leuven F. Capacitative calcium entry is directly activated by mutant presenilin-1 independent of the expression of the amyloid precursor protein.

The amount of Ca2+ absorbed is dependent on its availability in the diet and the absorption capacity of the intestine, and the absorption process is regulated at least in part by 1,25(OH)2D3. Approximately 200–300 mg/d of total luminal content of 1000 mg (800 mg daily uptake; 200 mg from pancreatic, biliary, and intestinal secretions) is absorbed, giving a gross GI absorption efficiency of 30%. This absorption is influenced by cellular and paracellular transport, systemic modulators of cell function, and intraluminal factors.

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