By Connie M. Weaver, Robert P. Heaney
This finished assessment of the country of our wisdom touching on calcium not just demonstrates its value to human healthiness, but additionally defines its many complicated roles. The authors summarize the newest uncomplicated clinical info at the mobile and metabolic services of calcium, explaining the prime innovations for appropriately measuring its bioavailability, absorption, and kinetics, and displaying that calcium deficiency is an enormous challenge whereas calcium extra an extraordinary one. additionally they study the advanced legislation of calcium absorption, distribution, and excretion, in addition to the a number of interactions of diet/lifestyle, and actual task in calcium homeostasis. Their dialogue of the explicit roles of calcium in a number of medical disorders-osteoporosis, oral well-being, weight problems, reproductive issues, and the metabolic syndrome-provides new insights and increases new questions. The advanced adjustments in calcium and phosphate law that take place in renal illness and the capability position of calcium in high blood pressure and vascular affliction also are addressed.
Read Online or Download Calcium in Human Health PDF
Best endocrinology & metabolism books
This well timed, improved new version is the definitive guide for skilled drug metabolism and pharmaceutical scientists and people new to the sphere. Written by way of across the world popular authors, it presents built-in, entire insurance of basic features of drug metabolism and the sensible purposes that aid consultant researchers via key demanding situations in glossy drug discovery and improvement.
This can be a 3-in-1 reference publication. It supplies an entire scientific dictionary protecting thousands of phrases and expressions in relation to glucose intolerance. It additionally offers large lists of bibliographic citations. ultimately, it presents details to clients on the best way to replace their wisdom utilizing a number of net assets.
Offers an updated evaluate of weight problems, its learn and medical parts. The textual content information issues starting from old views, definitions and dimension to the aetiology, pathophysiology, prevention and therapy of weight problems. It covers the impression of weight problems on a variety of stipulations, equivalent to diabetes, gout, arthritis, and center, pulmonary and gallbladder sickness, in addition to being pregnant.
Macromolecular (specifically peptide-based) medicinal drugs may probably be powerful medications. in spite of the fact that they've got a comparatively brief length of motion and variable healing index. An instance of this type of peptide is Glucagon-like Peptide I that can possibly be used as a progressive drug for diabetes.
- Teaching Professional Attitudes and Basic Clinical Skills to Medical Students: A Practical Guide
- Recent Advances in Transthyretin Evolution, Structure and Biological Functions
- Management and Leadership Skills for Medical Faculty: A Practical Handbook
- Anti-diabetes mellitus plants: active principles, mechanisms of action and sustainable utilization
Additional info for Calcium in Human Health
Hughes AR, Thastrup O, and Putney JW, Jr. Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool and not an inositol phosphate regulate calcium fluxes at the plasma membrane. J Biol Chem 1989;264:12,266– 12,271. 45. Putney JW, Jr. Capacitative calcium entry revisited. Cell Calcium 1990;11:611–624. 46. Putney JW, Jr, Bird GSJ. The inositol phosphate-calcium signaling system in no-excitable cells. Endocr Rev 1993;14:610–631.
Putney JW Jr. Type 3 inositol 1,4,5-trisphosphate receptor and capacitative calcium entry. Cell Calcium 1997;21:257–261. 13. Fagan KA, Graf RA, Tolman S, Schaack J, Cooper MF. Regulation of a Ca2+-sensitive adenylyl cyclase in an excitable cell. Role of voltage-gated versus capacitative Ca2+ entry. J Biol Chem 2000;275:40,187– 40,194. 14. Herms I, Schneider J, Dewachter I, Caluwaerts N, Kretzshmar H, Van Leuven F. Capacitative calcium entry is directly activated by mutant presenilin-1 independent of the expression of the amyloid precursor protein.
The amount of Ca2+ absorbed is dependent on its availability in the diet and the absorption capacity of the intestine, and the absorption process is regulated at least in part by 1,25(OH)2D3. Approximately 200–300 mg/d of total luminal content of 1000 mg (800 mg daily uptake; 200 mg from pancreatic, biliary, and intestinal secretions) is absorbed, giving a gross GI absorption efficiency of 30%. This absorption is influenced by cellular and paracellular transport, systemic modulators of cell function, and intraluminal factors.