Autoimmune Diseases in Endocrinology (Contemporary by Anthony P. Weetman

By Anthony P. Weetman

This can be a complete and novel textual content that examines key gains that predispose members to autoimmune ailments. the 1st part info the elemental mechanism of autoimmunity and examines immunogenetic and environmental elements in autoimmunity. the following part examines autoimmune thyroid illness. The 3rd part takes a glance at variety 1 diabetes mellitus. within the ultimate part, authors clarify different autoimmune endocrinopathies.

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Among humans, in contrast, it appears that genetic predisposition in total accounts for less than half of the susceptibility to autoimmune disease (10–12). Concurrence rates of 5–50% for T1DM and for autoimmune thyroid disease in genetically identical twins indicates that environmental agents as well as genetic factors are involved in the etiology of autoimmune endocrinopathies. A note of caution is needed. Not all non-inherited differences are due to external factors. During their generation of diversity, the lymphocyte receptors of the immune system undergo extensive, post-germline recombination.

50. Ueda H, Howson JM, Esposito L, et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 2003;423(6939):506–11. 51. Smyth D, Cooper JD, Collins JE, et al. Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Diabetes 2004;53(11):3020–3. Chapter 2 / Genetics and Autoimmunity 31 52. Criswell LA, Pfeiffer KA, Lum RF, et al. Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes.

Association of R602W in a protein tyrosine phosphatase gene with a high risk of rheumatoid arthritis in a British population: evidence for an early onset/disease severity effect. Arthritis Rheum 2005;52(1):358–60. 102. Simkins HM, Merriman ME, Highton J, et al. Association of the PTPN22 locus with rheumatoid arthritis in a New Zealand Caucasian cohort. Arthritis Rheum 2005;52(7):2222–5. 103. van Oene M, Wintle RF, Liu X, et al. Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn’s disease, in Canadian populations.

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