Atlas of Spleen Pathology by Dennis P. O'Malley (auth.)

By Dennis P. O'Malley (auth.)

The spleen is an organ which has diversified features together with immunologic and hematologic. The Atlas of Spleen Pathology describes and selectively illustrates the traditional and pathologic stipulations that afflict the spleen. This outstanding selection of prime quality electronic photographs will materially relief in carrying on with efforts to acknowledge, comprehend, and thoroughly interpret the gross and lightweight microscopic findings in spleens.

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Early involvement of spleen with CLL. There is only minimal distortion of white pulp structures and an increase in red pulp small lymphocytes. Splenic findings of early CLL and “monoclonal B cell lymphocytosis” would be difficult to differentiate without clinical information Fig. 28 Chronic lymphocytic leukemia. 2 Chronic Lymphocytic Leukemia Fig. 29 Chronic lymphocytic leukemia. High magnification of splenic red pulp in CLL. There is an increase in small lymphocytes within cords and sinuses, as well as some nodular aggregates surrounding a small vessel (center), likely representing a PALS region 25 Fig.

Note that the abnormal lymphocytes are predominantly small with irregular nuclei. Large cells are less than 5 per highpower field (HPF), although this number should be correlated with the composition of several follicles and averaged Fig. 48 Follicular lymphoma. An example of an abnormal follicle of low-grade follicular lymphoma, with preservation of the marginal zone Fig. 51 Follicular lymphoma. Cytologic composition of follicular lymphoma grade 2. Note that the abnormal lymphocytes are predominantly small with irregular nuclei but there are some large transformed cells present (5–15 per HPF) Fig.

In this low-magnification image, there is an overall increase in number and size of white pulp structures. In this example of mantle cell lymphoma, there are also some small nodules of lymphocytes within the red pulp. These features can be seen in other small B-cell lymphomas in the spleen Fig. 57 Mantle cell lymphoma. Mantle cell lymphoma most often has a white pulp distribution in the spleen. In this case, there is preservation of marginal zone or “monocytoid” differentiation of the mantle cell lymphoma.

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