By Aart Jan van der Lely, Albert Beckers, Adrian Daly, Steven W. Lamberts, David R. Clemmons
This e-book stories the pathophysiology and actual manifestations of acromegaly and discusses the a number of healing procedures now on hand for the administration of the sufferer with acromegaly. The e-book includes an abundant variety of illustrations that support to stress issues of specific curiosity, together with radiological, histopathological, and actual prognosis pictures. Sections are dedicated to detailing very important subject matters together with determinants of pathological results of ailment job in acromegaly, person healing offerings and standards for analysis, and illness keep watch over.
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Extra info for Acromegaly: Pathology, Diagnosis and Treatment
Source: United States National Library of Medicine EARLY 20TH CENTURY TO PRESENT DAY: PHYSIOLOGY AND PHARMACOTHERAPY In contrast to the pioneering spirit encountered during the first 25 years of the 20th century, the subsequent history of pituitary endocrinology is one characterized by gains in understanding that came at the cost of extraordinarily laborious experimental methods. While thyroid hormone and insulin were discovered at an early stage (1914 and 1921, respectively), pituitary hormones were not isolated until the 1940s in a series of experiments led by the celebrated protein chemist Choh Hao Li (Fig.
PAS orange stain) Source: J. Trouillas Figure 2 High-power magnification of the border zone separating a GH-secreting pituitary adenoma from surrounding normal pituitary tissue. (PAS orange stain) Source: J. Trouillas 3. Epidemiology, Pathology, and Complications 43 One of the more frequent subclassifications of GH-secreting pituitary tumors divides tumors by intracellular granule number into densely granulated and sparsely granulated adenomas (Figs. 3–6). These two morphological types differ in their clinical behavior, with sparsely granulated tumors more likely to be macroadenomas, to have a higher rate of extension and/or invasiveness, and to have poorer responses to somatostatin analogs (21).
Transsphenoidal and transcranial surgery for pituitary adenomas. J Neuro-Oncol 2004; 69:237–256. 22. Schloffer H. Erfolgreiche Operation eines Hypophysentumors auf nasalem Wege. Wien Klin Wochenschr 1907; 20:621–624. 23. Artico M, Pastore FS, Fraioli B, Giuffre´ R. The contributions of Davide Giordano (1864–1954) to pituitary surgery: the transglabellar–nasal approach. Neurosurgery 1998; 42:909–912. 24. Kocher T. Ein Fall von Hypophysis-tumor mit operativer Heilung. Dtsch Z Chir 1909; 100:13–37.